2. Academic Validation
  3. Carbazole alkaloids from the peels of Clausena lansium

Carbazole alkaloids from the peels of Clausena lansium

  • J Asian Nat Prod Res. 2014 Oct;16(10):1024-8. doi: 10.1080/10286020.2014.930442.
Hui-Dong Deng 1,  Wen-Li Mei,  Hui Wang,  Zhi-Kai Guo,  Wen-Hua Dong,  Hao Wang,  Shao-Peng Li,  Hao-Fu Dai
Affiliations

Affiliation

  • 1 a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
PMID: 24993293 DOI: 10.1080/10286020.2014.930442
Abstract

A new carbazole alkaloid, claulansine K (1), together with six known carbazole Alkaloids (2-7), was isolated from the peels of Clausena lansium (Lour.) Skeels. The new compound was elucidated using a combination of 1D and 2D NMR (HMQC, HMBC, COSY, and ROESY) techniques, and HR-EI-MS analyses. Compound 1 showed in vitro α-glucosidase inhibitory activity with the IC50 value of 0.11 mM. Compound 2 exhibited moderate Antibacterial activity against Staphylococcus aureus with the diameter of inhibition zone of 14.2 mm.

Keywords

Clausena lansium; Rutaceae; antibacterial activity; carbazole alkaloids; α-glucosidase inhibitory activity.

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