2. Academic Validation
  3. Theasaponin E₁ as an effective ingredient for anti-angiogenesis and anti-obesity effects

Theasaponin E₁ as an effective ingredient for anti-angiogenesis and anti-obesity effects

  • Biosci Biotechnol Biochem. 2014;78(2):279-87. doi: 10.1080/09168451.2014.893183.
Jong-Deog Kim 1,  Narendra Chaudhary,  Hyo-Jin Seo,  Min-Yong Kim,  Tai-Sun Shin
Affiliations

Affiliation

  • 1 a Department of Biotechnology , Chonnam National University , Yeosu , Korea.
PMID: 25036682 DOI: 10.1080/09168451.2014.893183
Abstract

Theasaponin E₁ (TSE₁) has been suggested to have higher biological activity than Other saponins present in tea seed. Saponins have recently been considered as a potential chemotherapeutic agent for treating Cancer. We examined the anti-angiogenic and anti-obesity properties of TSE₁ contributing to anti-cancer efficacy. Treating with a 10 μg/mL concentration of TSE₁ completely inhibited tube formation in human umbilical vein endothelial cells (HUVECs). TSE₁ showed toxicity toward Cancer cells and inhibited in vivo growth of the tumor. The vascular endothelial growth factor (VEGF) receptor complex was suppressed, leading to the inhibition of protein kinase B (Akt) expression and down-regulation of nuclear factor-kappa B (NF-kB) activation. The differentiating 3T3-L₁ cells treated with TSE₁ had decreased lipid droplet formation measured by Oil Red O staining. Reduced weight was measured in mice fed with a TSE₁ plus high-fat diet. The results taken together, and particularly the NF-kB inhibition, suggest that TSE₁ may have multi-target action for treating Cancer as a novel chemotherapeutic agent.

Keywords

NF-kB; VEGF; anti-angiogenesis; anti-obesity; theasaponin E1.

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