2. Academic Validation
  3. The coronavirus nucleocapsid is a multifunctional protein

The coronavirus nucleocapsid is a multifunctional protein

  • Viruses. 2014 Aug 7;6(8):2991-3018. doi: 10.3390/v6082991.
Ruth McBride 1,  Marjorie van Zyl 2,  Burtram C Fielding 3
Affiliations

Affiliations

  • 1 Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, Faculty of Natural Sciences, University of the Western Cape, Private Bag X17, Modderdam Road, Bellville, Western Cape 7535, South Africa. [email protected].
  • 2 Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, Faculty of Natural Sciences, University of the Western Cape, Private Bag X17, Modderdam Road, Bellville, Western Cape 7535, South Africa. [email protected].
  • 3 Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, Faculty of Natural Sciences, University of the Western Cape, Private Bag X17, Modderdam Road, Bellville, Western Cape 7535, South Africa. [email protected].
PMID: 25105276 DOI: 10.3390/v6082991
Abstract

The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multifunctional protein. The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions of the protein.

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