2. Academic Validation
  3. Phosphorylation and dephosphorylation of the natriuretic peptide urodilatin (CDD-/ANP-95-126) and the effect on biological activity

Phosphorylation and dephosphorylation of the natriuretic peptide urodilatin (CDD-/ANP-95-126) and the effect on biological activity

  • Biochem Biophys Res Commun. 1989 Sep 15;163(2):830-5. doi: 10.1016/0006-291x(89)92297-3.
T Dörner 1,  M Gagelmann,  S Feller,  F Herbst,  W G Forssmann
Affiliations

Affiliation

  • 1 Institut für Anatomie und Zellbiologie III, Universität Heidelberg, FRG.
PMID: 2528951 DOI: 10.1016/0006-291x(89)92297-3
Abstract

Urodilatin (CDD-/ANP-95-126), a new peptide hormone from human urine, is comprised of the same amino acid sequence as cardiodilatin (CDD-99-126/alpha-hANP) except for N-terminal extention by four amino acid residues. The presence of the recognition sequence Arg101-Arg-Ser-Ser104 for the cyclic AMP-dependent protein kinase enables rapid phosphorylation in the Ser104-position. Phosphorylation of urodilatin is associated with decreased vasorelaxant potency, while dephosphorylation of "phospho-urodilatin" by acidic Phosphatase completely restores bioactivity.

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