2. Academic Validation
  3. Bioactive thiazole and benzothiazole derivatives

Bioactive thiazole and benzothiazole derivatives

  • Eur J Med Chem. 2015 Jun 5:97:911-27. doi: 10.1016/j.ejmech.2014.10.058.
Abdul Rouf 1,  Cihangir Tanyeli 2
Affiliations

Affiliations

  • 1 Department of Chemistry, Middle East Technical University (METU), 06800 Ankara, Turkey.
  • 2 Department of Chemistry, Middle East Technical University (METU), 06800 Ankara, Turkey. Electronic address: [email protected].
PMID: 25455640 DOI: 10.1016/j.ejmech.2014.10.058
Abstract

The heterocycles are the versatile compounds existing in almost all natural products and synthetic organic compounds, usually associated with one or the Other biological activity. Among the heterocycles the thiazoles and benzothiazoles occupy a prominent position. They possess a broad range of biological activities and are found in many potent biologically active molecules and drugs such as vitamin thiamine, sulfathiazol (antimicrobial drug), ritonavir (antiretroviral drug), abafungin (Antifungal drug) and tiazofurin (antineoplastic drug). The thiazole moiety is abundantly found in natural products while benzothiazole moiety is rare. In this review we disclose the literature reports of thiazoles and benzothiazoles possessing different biological activities.

Keywords

Antibacterial activity; Anticancer activity; Benzothiazoles; Heterocycles; Thiazoles.

Figures
Products