Abafungin (Synonyms: BAY-W-6341)

Cat. No.: HY-119847 Purity: 99.10%: Data Sheet
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Abafungin (BAY-W-6341) is a broad-spectrum fungicidal arylguanidine compound and a selective inhibitor of sterol-C-24-methyltransferase. Abafungin blocks the transmethylation reaction at the C-24 position of the sterol side chain during the ergosterol biosynthesis pathway. Abafungin directly disrupts fungal cell membrane integrity, and diminishes fungal viability independent of the fungal growth state. Abafungin can be applied to the research of fungal infections, particularly dermatomycoses.

For research use only. We do not sell to patients.

Abafungin Chemical Structure

CAS No. : 129639-79-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

In Vitro

Abafungin (0.1-1 μg/mL; 24 h for Candida albicans, 3–5 days for other fungi) exhibits broad-spectrum in vitro antifungal activity against dermatophytes, Candida spp.,Aspergillus spp. and with species-specific MIC values ranging from ≤ 0.06 to 16 μg/mL^[1].
Abafungin (10 μg/mL; 48 h for C. albicans, 3-5 days for other fungi) completely inhibits C. albicans at 10 μg/mL after 48 h, with species-specific MFC values ranging from ≤ 0.06 to 32 μg/mL^[1].
Abafungin disrupts the cell membrane integrity of Candida albicans in a concentration-dependent manner and induces rapid ion release within 2 min at concentrations ≥ 10 μg/mL. For strain TIMM 0144, approximately 85% of total potassium is released within 2 min at 40 μg/mL^[1].
Abafungin (30 μg/mL; up to 30 min) triggers rapid ATP leakage, ATP degradation, and loss of viability in resting Candida albicans strain H12, whereas growing cells show transient ATP elevation, reduced ATP leakage, and delayed loss of viability^[1].
Abafungin (5×10^-5 M for phosphatidylserine, 1×10^-4 M for other substances; 1 min at 22°C) displays strong and specific interaction with purified phosphatidylserine, while showing no or only weak interaction with other tested phospholipids and sterols^[1].
Abafungin (0.01-10 μg/mL; 3 h) dose-dependently inhibits ergosterol biosynthesis in Candida albicans by reducing the incorporation of L-[methyl-¹⁴C]methionine into sterols^[1].
Abafungin (1 μg/mL; 24 h) inhibits sterol-C-24-methyltransferase in Candida albicans strain TIMM 0144, leading to the accumulation of lanosterol in the ergosterol biosynthesis pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

378.49

Formula

C₂₁H₂₂N₄OS

CAS No.

129639-79-8

Appearance

Solid

Color

White to off-white

SMILES

CC1=CC(C)=C(OC2=CC=CC=C2C3=CSC(NC4=NCCCN4)=N3)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (132.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6421 mL	13.2104 mL	26.4208 mL
5 mM	0.5284 mL	2.6421 mL	5.2842 mL
10 mM	0.2642 mL	1.3210 mL	2.6421 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.10%

Select Batch:

Data Sheet (279 KB) SDS (394 KB)

COA (257 KB) HNMR (254 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Borelli C, et al. Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi. Chemotherapy. 2008;54(4):245-259. [Content Brief]

[2]. Rouf A, et al. Bioactive thiazole and benzothiazole derivatives. Eur J Med Chem. 2015;97:911-927.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6421 mL	13.2104 mL	26.4208 mL	66.0519 mL
	5 mM	0.5284 mL	2.6421 mL	5.2842 mL	13.2104 mL
	10 mM	0.2642 mL	1.3210 mL	2.6421 mL	6.6052 mL
	15 mM	0.1761 mL	0.8807 mL	1.7614 mL	4.4035 mL
	20 mM	0.1321 mL	0.6605 mL	1.3210 mL	3.3026 mL
	25 mM	0.1057 mL	0.5284 mL	1.0568 mL	2.6421 mL
	30 mM	0.0881 mL	0.4403 mL	0.8807 mL	2.2017 mL
	40 mM	0.0661 mL	0.3303 mL	0.6605 mL	1.6513 mL
	50 mM	0.0528 mL	0.2642 mL	0.5284 mL	1.3210 mL
	60 mM	0.0440 mL	0.2202 mL	0.4403 mL	1.1009 mL
	80 mM	0.0330 mL	0.1651 mL	0.3303 mL	0.8256 mL
	100 mM	0.0264 mL	0.1321 mL	0.2642 mL	0.6605 mL

Abafungin Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abafungin129639-79-8BAY-W-6341FungaldermatomycosesCandida albicansfungal infectionsfungal cell membranesdermatophytesinvasive fungal infectionsergosterol biosynthesisCandida spp.sterol-C-24-methyltransferaseAspergillus spp.Inhibitorinhibitorinhibit

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Abafungin (Synonyms: BAY-W-6341)

Abafungin Related Antibodies

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