129639-79-8
Chemical Structure
Abafungin
Synonym(s): BAY-W-6341
- CAS No.: 129639-79-8
- Formula:C21H22N4OS
- Molecular Weight:378.49
IUPAC Name: 4-(2-(2,4-dimethylphenoxy)phenyl)-N-(1,4,5,6-tetrahydropyrimidin-2-yl)thiazol-2-amine
InChIKey: TYBHXIFFPVFXQW-UHFFFAOYSA-N
SMILES: CC1=CC(C)=C(OC2=CC=CC=C2C3=CSC(NC4=NCCCN4)=N3)C=C1
Biological Activity: Abafungin (BAY-W-6341) is a broad-spectrum fungicidal arylguanidine compound and a selective inhibitor of sterol-C-24-methyltransferase. Abafungin blocks the transmethylation reaction at the C-24 position of the sterol side chain during the ergosterol biosynthesis pathway. Abafungin directly disrupts fungal cell membrane integrity, and diminishes fungal viability independent of the fungal growth state. Abafungin can be applied to the research of fungal infections, particularly dermatomycoses[1][2].
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Abafungin | 99.10% | Abafungin (BAY-W-6341) is a broad-spectrum fungicidal arylguanidine compound and a selective inhibitor of sterol-C-24-methyltransferase. Abafungin blocks the transmethylation reaction at the C-24 position of the sterol side chain during the ergosterol biosynthesis pathway. Abafungin directly disrupts fungal cell membrane integrity, and diminishes fungal viability independent of the fungal growth state. Abafungin can be applied to the research of fungal infections, particularly dermatomycoses. | ||||||||||||||||||||
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- [1]. Borelli C, et al. Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi. Chemotherapy. 2008;54(4):245-259. [Content Brief]
- [2]. Rouf A, et al. Bioactive thiazole and benzothiazole derivatives. Eur J Med Chem. 2015;97:911-927. [Content Brief]
Keywords
