Nek2/Hec1-IN-1
N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide is a derivative of INH1 with anticancer activity. It is cytotoxic to MDA-MB-231, MDA-MB-488, HeLa, and K562 cells (IC50s=1.1, 3.4, 1.6, and 1.2 μM, respectively).
For research use only. We do not sell to patients.
- CAS No.: 560103-80-2
- Formula: C17H15N3OS
- Molecular Weight:309.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
1.6 μM
Compound: 13
|
Cytotoxicity against human HeLa cells after 4 days by XTT assay
Cytotoxicity against human HeLa cells after 4 days by XTT assay
|
[PMID: 19243176] |
| K562 | IC50 |
1.2 μM
Compound: 13
|
Cytotoxicity against human K562 cells after 4 days by XTT assay
Cytotoxicity against human K562 cells after 4 days by XTT assay
|
[PMID: 19243176] |
| MDA-MB-231 | IC50 |
1.1 μM
Compound: 13
|
Cytotoxicity against human MDA-MB-231 cells after 4 days XTT assay
Cytotoxicity against human MDA-MB-231 cells after 4 days XTT assay
|
[PMID: 19243176] |
| MDA-MB-468 | IC50 |
3.4 μM
Compound: 13
|
Cytotoxicity against human MDA-MB-468 cells after 4 days by XTT assay
Cytotoxicity against human MDA-MB-468 cells after 4 days by XTT assay
|
[PMID: 19243176] |
Chemical Information
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CAS No. 560103-80-2
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Molecular Weight 309.39
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Formula C17H15N3OS
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SMILES
O=C(C1=CC=NC=C1)NC2=NC(C3=CC=C(C)C=C3C)=CS2
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Synonyms
Nec2/Hec1 inhibitor
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)