2. Academic Validation
  3. Alkaloidal metabolites from a marine-derived Aspergillus sp. fungus

Alkaloidal metabolites from a marine-derived Aspergillus sp. fungus

  • J Nat Prod. 2015 Mar 27;78(3):349-54. doi: 10.1021/np500683u.
Lijuan Liao 1,  Minjung You 1,  Beom Koo Chung 2,  Dong-Chan Oh 1,  Ki-Bong Oh 2,  Jongheon Shin 1
Affiliations

Affiliations

  • 1 †Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
  • 2 ‡Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea.
PMID: 25581396 DOI: 10.1021/np500683u
Abstract

Fumiquinazoline S (1), a new quinazoline-containing alkaloid, and the known fumiquinazolines F (6) and L (7) of the same structural class were isolated from the solid-substrate culture of an Aspergillus sp. fungus collected from marine-submerged wood. In addition, isochaetominines A-C (2-4) and 14-epi-isochaetominine C (5), new Alkaloids possessing an unusual amino acid-based tetracyclic core framework related to the fumiquinazolines, were isolated from the same Fungal strain. The structures of these compounds were determined by combined spectroscopic methods, and the absolute configurations were assigned by NOESY, ROESY, and advanced Marfey's analyses along with biogenetic considerations. The new compounds exhibited weak inhibition against Na(+)/K(+)-ATPase.

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