2. Academic Validation
  3. Antimicrobial and cytotoxic phenolics and phenolic glycosides from Sargentodoxa cuneata

Antimicrobial and cytotoxic phenolics and phenolic glycosides from Sargentodoxa cuneata

  • Fitoterapia. 2015 Mar:101:153-61. doi: 10.1016/j.fitote.2015.01.008.
Xiaobin Zeng 1,  Hai Wang 2,  Zhongqing Gong 3,  Jinghui Huang 4,  Weijing Pei 4,  Xueyan Wang 4,  Jingzhao Zhang 4,  Xudong Tang 5
Affiliations

Affiliations

  • 1 Key Lab for New Drug Research of TCM and Shenzhen Branch, State R&D Centre for Viro-Biotech, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, Guangdong, People's Republic of China; Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, Zhanjiang 524023, Guangdong, People's Republic of China. Electronic address: [email protected].
  • 2 Key Lab for New Drug Research of TCM and Shenzhen Branch, State R&D Centre for Viro-Biotech, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, Guangdong, People's Republic of China; School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
  • 3 Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, Zhanjiang 524023, Guangdong, People's Republic of China.
  • 4 Key Lab for New Drug Research of TCM and Shenzhen Branch, State R&D Centre for Viro-Biotech, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, Guangdong, People's Republic of China.
  • 5 Key Lab for New Drug Research of TCM and Shenzhen Branch, State R&D Centre for Viro-Biotech, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, Guangdong, People's Republic of China. Electronic address: [email protected].
PMID: 25598187 DOI: 10.1016/j.fitote.2015.01.008
Abstract

Five new phenolic glycosides, Sargentodosides A-E, and two new dihydronaphthalene Lignans, Sargentodognans F-G, together with thirty-two known phenolic compounds were isolated from the 60% ethanol extracts of Sargentodoxa cuneata. Their structures including absolute configurations were determined by spectroscopic analysis and electronic circular dichroism experiments. In bioscreening experiments, twelve compounds (22-26, 29, 33-34, 36, 38) exhibited Antibacterial activities against S. aureus ATCC 29213 with minimum inhibitory concentration (MIC) values of 2-516μg/mL. And compound 29 showed the highest Antibacterial activity against S. aureus ATCC 29213 with MIC values of 2μg/mL, while the MIC values of levofloxacin was 8μg/mL. Three compounds (29, 33, 36) exhibited Antibacterial activities against S. aureus ATCC 25923 with MIC values of 256-516μg/mL. Two compounds (29, 33) exhibited Antibacterial activities against A. baumanii ATCC 19606 with MIC values of 128-516μg/mL. However, no compound exhibited antimicrobial activities against C. albicans ATCC 10231. Moreover, three compounds (10, 25, 36) exhibited significant inhibition of proliferation in the two cell lines Hela and Siha, and showed stronger inhibitive activity of these two selected cell lines than cisplatin in the cytotoxic assay. Thus, S. cuneata is a potential plant source for further research targeting bacteria and Cancer diseases.

Keywords

Antimicrobial activity; Cytotoxic activity; Dihydronaphthalene lignan; Phenolic glycosides; Sargentodoxa cuneata.

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