2. Academic Validation
  3. Hepatoprotective triterpene saponins from the roots of Glycyrrhiza inflata

Hepatoprotective triterpene saponins from the roots of Glycyrrhiza inflata

  • Molecules. 2015 Apr 9;20(4):6273-83. doi: 10.3390/molecules20046273.
Yun-Feng Zheng 1 2,  Juan-Hua Wei 3,  Shi-Qi Fang 4,  Yu-Ping Tang 5 6,  Hai-Bo Cheng 7,  Tian-Lin Wang 8,  Cun-Yu Li 9 10,  Guo-Ping Peng 11 12
Affiliations

Affiliations

  • 1 School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. [email protected].
  • 2 Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China. [email protected].
  • 3 School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. [email protected].
  • 4 School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. [email protected].
  • 5 School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. [email protected].
  • 6 Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China. [email protected].
  • 7 Translational Medicine Research Center of Nanjing University of Chinese Medicine, Nanjing 210023, China. [email protected].
  • 8 School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. [email protected].
  • 9 School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. [email protected].
  • 10 Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China. [email protected].
  • 11 School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. [email protected].
  • 12 Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China. [email protected].
PMID: 25859783 DOI: 10.3390/molecules20046273
Abstract

Two novel oleanane-type triterpene saponins, licorice-saponin P2 (1) and licorice-saponin Q2 (3), together with nine known compounds 2, 4-11, have been isolated from the water extract of the roots of Glycyrrhiza inflata. The structures of these compounds were elucidated on the basis of spectroscopic analysis, including 2D-NMR experiments (1H-1H COSY, HSQC, HMBC and ROESY). In in vitro assays, compounds 2-4, 6 and 11 showed significant hepatoprotective activities by lowering the ALT and AST levels in primary rat hepatocytes injured by D-galactosamine (D-GalN). In addition, compounds 2-4, 6, 7 and 11 were found to inhibit the activity of PLA2 with IC50 values of 6.9 μM, 3.6 μM, 16.9 μM, 27.1 μM, 32.2 μM and 9.3 μM, respectively, which might be involved in the regulation of the hepatoprotective activities observed.

Figures
Products