2. Academic Validation
  3. Progress in Studies on Rutaecarpine. II.--Synthesis and Structure-Biological Activity Relationships

Progress in Studies on Rutaecarpine. II.--Synthesis and Structure-Biological Activity Relationships

  • Molecules. 2015 Jun 11;20(6):10800-21. doi: 10.3390/molecules200610800.
Jong-Keun Son 1,  Hyeun Wook Chang 2,  Yurngdong Jahng 3
Affiliations

Affiliations

  • 1 College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Korea. [email protected].
  • 2 College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Korea. [email protected].
  • 3 College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Korea. [email protected].
PMID: 26111170 DOI: 10.3390/molecules200610800
Abstract

Rutaecarpine is a pentacyclic indolopyridoquinazolinone alkaloid found in Evodia rutaecarpa and Other related herbs. It has a variety of intriguing biological properties, which continue to attract the academic and industrial interest. Studies on rutaecarpine have included isolation from new natural sources, development of new synthetic methods for its total synthesis, the discovery of new biological activities, metabolism, toxicology, and establishment of analytical methods for determining rutaecarpine content. The present review focuses on the synthesis, biological activities, and structure-activity relationships of rutaecarpine derivatives, with respect to their antiplatelet, vasodilatory, cytotoxic, and anticholinesterase activities.

Keywords

alkaloid; anti-cholinesterase activity; anti-obesity activity; anticancer activity; antiplatelet activity; rutaecarpine; vasodilatory activity.

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