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  6. 13b,14-Dihydrorutaecarpine

13b,14-Dihydrorutaecarpine is a cytotoxin derived from dihydrorutaecarpine. 13b,14-Dihydrorutaecarpine exerts selective cytotoxicity against central nervous system (CNS) and prostate cancer cell lines (GI50=0.02 μM and 0.2 μM). 13b,14-Dihydrorutaecarpine can be used in the research of central nervous system (CNS) cancer, ovarian cancer, prostate cancer and renal cancer.

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13b,14-Dihydrorutaecarpine

13b,14-Dihydrorutaecarpine Chemical Structure

CAS No. : 59863-00-2

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13b,14-Dihydrorutaecarpine Related Antibodies

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Description

13b,14-Dihydrorutaecarpine is a cytotoxin derived from dihydrorutaecarpine. 13b,14-Dihydrorutaecarpine exerts selective cytotoxicity against central nervous system (CNS) and prostate cancer cell lines (GI50=0.02 μM and 0.2 μM). 13b,14-Dihydrorutaecarpine can be used in the research of central nervous system (CNS) cancer, ovarian cancer, prostate cancer and renal cancer[1].

In Vitro

13b,14-Dihydrorutaecarpine (compound 29a) potently inhibits the growth of human central nervous system cancer cell line U251, human prostate cancer cell line DU145 and human ovarian cancer cell line SKOV3, with GI50 values of 0.02 μM, 0.2 μM and 3 μM, respectively[1].
13b,14-Dihydrorutaecarpine shows weak activity against human lung cancer cell line H522 and human renal cancer cell line ACHN, and exhibits no activity against melanoma cell line UACC62[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

13b,14-Dihydrorutaecarpine Related Antibodies
Molecular Weight

289.33

Formula

C18H15N3O
CAS No.
SMILES

O=C1C2=C(NC3C4=C(CCN13)C5=C(C=CC=C5)N4)C=CC=C2
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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13b,14-Dihydrorutaecarpine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

13b,14-Dihydrorutaecarpine59863-00-2OthersU251 human CNS cancer cellsACHN human renal cancer cellsCNS cancerrenal cancerovarian cancerSKOV3 human ovarian cancer cellsCNS cancer cell linesDU145 human prostate cancer cellsprostate cancer cell linesprostate cancerInhibitorinhibitorinhibit

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