2. Academic Validation
  3. A thiol-thiosulfonate reaction providing a novel strategy for turn-on thiol sensing

A thiol-thiosulfonate reaction providing a novel strategy for turn-on thiol sensing

  • Chem Commun (Camb). 2015 Oct 14;51(80):14913-6. doi: 10.1039/c5cc05390k.
Chunpo Ge 1,  Hao Wang,  Baoxin Zhang,  Juan Yao,  Xinming Li,  Weimin Feng,  Panpan Zhou,  Yawen Wang,  Jianguo Fang
Affiliations

Affiliation

  • 1 State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. [email protected].
PMID: 26305001 DOI: 10.1039/c5cc05390k
Abstract

The first thiol-specific turn-on probe, BODIPY-TS, utilizing a thiosulfonate scaffold as the thiol recognition unit was reported. BODIPY-TS displays low toxicity, and features high sensitivity, fast response and quantitative reaction towards thiols. The structural novelty of BODIPY-TS would guide the development of novel thiol probes.

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