1. Academic Validation
  2. Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis

Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis

  • J Nat Prod. 2015 Nov 25;78(11):2846-9. doi: 10.1021/acs.jnatprod.5b00746.
Alain S Leutou Inho Yang Heonjoong Kang Eun Kyung Seo Sang-Jip Nam William Fenical 1
Affiliations

Affiliation

  • 1 Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego , La Jolla, California 92093-0204, United States.
Abstract

Chemical investigation of a marine-derived actinomycete isolated from marine sediments collected off the coast of southern California and identified as a Nocardiopsis sp. (strain CNQ115) led to the isolation of two new 4-aminoimidazole Alkaloids, nocarimidazoles A (1) and B (2). The chemical structures of nocarimidazoles A and B were assigned by interpretation of NMR spectroscopic data and through methylation to yield monomethyl and dimethyl derivatives. Nocarimidazoles A and B possess a 4-aminoimidazole ring combined with a conjugated carbonyl side chain, which is rarely found in microbial secondary metabolites.

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