2. Academic Validation
  3. Cytotoxic and anti-inflammatory activities of phenanthrenes from the medullae of Juncus effusus L

Cytotoxic and anti-inflammatory activities of phenanthrenes from the medullae of Juncus effusus L

  • Arch Pharm Res. 2016 Feb;39(2):154-160. doi: 10.1007/s12272-015-0680-x.
Wei Ma 1,  Yue Zhang 1,  Yun-Yun Ding 1,  Feng Liu 1,  Ning Li 2
Affiliations

Affiliations

  • 1 School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
  • 2 School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China. [email protected].
PMID: 26584913 DOI: 10.1007/s12272-015-0680-x
Abstract

Bioactivity guided phytochemical investigation of the ethanol extract of the medullae of Juncus effusus resulted in the isolation of two new phenanthrenes, 8-hydroxymethyl-2-hydroxyl-1-methyl-5-vinyl-9,10-dihydrophenanthrene (1), and 5-(1-methoxyethyl)-1-methyl-phenanthren-2,7-diol (2) together with 15 known phenanthrenoids (3-17). The chemical structures of 1 and 2 were established by a combination of spectroscopic techniques. Compounds 1-15 and 17 were evaluated for their cytotoxic activities against five human Cancer cell lines (SHSY-5Y, SMMC-7721, HepG-2, Hela and MCF-7) by CCK-8 assay, and their anti-inflammatory activities were also evaluated by inhibition on NO production in LPS-activated murine macrophage RAW 264.7 cells.

Keywords

Anti-inflammatory activity; Cytotoxicity; Juncaceae; Juncus effuses; Phenanthrene.

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