2. Academic Validation
  3. Lignans from the rhizomes of Iris tectorum

Lignans from the rhizomes of Iris tectorum

  • Fitoterapia. 2016 Jan:108:93-7. doi: 10.1016/j.fitote.2015.11.020.
Chun-Lei Zhang 1,  Yan Wang 2,  Yan-Fei Liu 2,  Dong Liang 2,  Zhi-You Hao 2,  Huan Luo 2,  Ruo-Yun Chen 2,  De-Quan Yu 3
Affiliations

Affiliations

  • 1 Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of TCM, China Pharmaceutical University, Nanjing 211198, People's Republic of China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • 2 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • 3 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: [email protected].
PMID: 26625840 DOI: 10.1016/j.fitote.2015.11.020
Abstract

Chemical examination of the ethanol extract of rhizomes of Iris tectorum led to the isolation and characterization of three new Lignans, (7R,7'R,8S,8'S)-5'-methoxy-neo-olivil (1a), (7S,7'S,8R,8'R) -5'-methoxy-neo-olivil (1b), (7S,7'R,8S,8'S)-neo-olivil (2a), (7R,7'S,8R,8'R)-neo-olivil (2b), (7R,7'R,8S,8'S,7''S,8''S)-threo-neo-olivil-4'-O-8-guaiacylglycerol ether (3), together with six known ones (4-9). Among them, compounds 1 and 2 were found to be racemic mixtures, respectively, which were verified by chiral HPLC analysis, compound 3 was a new sesquineolignan. The structures were elucidated on the basis of extensive spectroscopic analysis. To our knowledge, this is the first report of lignan constituents isolated from I. tectorum. All compounds were evaluated for their cytotoxicity against five human tumor cell lines and none of them displayed significant toxicity in tested cell lines at a concentration of 10 μM.

Keywords

Cytotoxicity; Iris tectorum; Lignans; Racemic mixtures; Sesquineolignan.

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