2. Academic Validation
  3. A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model

A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model

  • Chem Commun (Camb). 2016 Feb 7;52(11):2296-9. doi: 10.1039/c5cc09998f.
Yaping Liu 1,  Huilong Ma 1,  Liangwei Zhang 1,  Yajing Cui 1,  Xiaoting Liu 1,  Jianguo Fang 1
Affiliations

Affiliation

  • 1 State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. [email protected].
PMID: 26725656 DOI: 10.1039/c5cc09998f
Abstract

The first off-on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.

Figures
Products