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Mito-TRFS 

Cat. No.: HY-D1250
Handling Instructions

Mito-TRFS, the first off-on probe, is used to image the mitochondrial thioredoxin reductase (TrxR2) in live cells.

For research use only. We do not sell to patients.

Mito-TRFS Chemical Structure

Mito-TRFS Chemical Structure

CAS No. : 1859102-62-7

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Description

Mito-TRFS, the first off-on probe, is used to image the mitochondrial thioredoxin reductase (TrxR2) in live cells[1].

In Vitro

Mito-TRFS (10 μM) has the maximal absorption at ~375 nm in TE buffer (50 mM Tris-HCl and 1 mM EDTA, pH 7.4) at 37 °C[1].
Mito-TRFS itself has a strong emission at ~480 nm when excited at 375 nm in TE buffer (φ=0.34), but has weak emission when excited at 438 nm[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence[1].

Cell Line: HeLa cells.
Concentration: 1 μM.
Incubation Time: 2 h.
Result: Mito-TRFS is localized predominantly in the mitochondria of live cells.
Molecular Weight

820.70

Formula

C₃₈H₃₄IN₂O₅PS₂

CAS No.

1859102-62-7

SMILES

O=C(C1=CC=C(NC(OC2CSSC2)=O)C3=CC=CC4=C13)N(CCOCC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)C4=O.[I-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Mito-TRFSOthersParkinson'sHeLamitochondrialthioredoxinreductaseInhibitorinhibitorinhibit

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