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  3. Fluorescent Dye
  4. Mito-TRFS

Mito-TRFS, the first off-on probe, is used to image the mitochondrial thioredoxin reductase (TrxR2) in live cells.

For research use only. We do not sell to patients.

Mito-TRFS Chemical Structure

Mito-TRFS Chemical Structure

CAS No. : 1859102-62-7

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Based on 1 publication(s) in Google Scholar

Mito-TRFS Related Antibodies

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Description

Mito-TRFS, the first off-on probe, is used to image the mitochondrial thioredoxin reductase (TrxR2) in live cells[1].

In Vitro

Mito-TRFS (10 μM) has the maximal absorption at ~375 nm in TE buffer (50 mM Tris-HCl and 1 mM EDTA, pH 7.4) at 37 °C[1].
Mito-TRFS itself has a strong emission at ~480 nm when excited at 375 nm in TE buffer (φ=0.34), but has weak emission when excited at 438 nm[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mito-TRFS Related Antibodies

Immunofluorescence[1].

Cell Line: HeLa cells.
Concentration: 1 μM.
Incubation Time: 2 h.
Result: Mito-TRFS is localized predominantly in the mitochondria of live cells.
Molecular Weight

820.70

Formula

C38H34IN2O5PS2
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

Emission (Em)

525
Excitation (Ex)

486
SMILES

O=C(C1=CC=C(NC(OC2CSSC2)=O)C3=CC=CC4=C13)N(CCOCC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)C4=O.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 95.75%

COA (255 KB) RP-HPLC (246 KB) MS (173 KB)

Handling Instructions (2659 KB)
References
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Mito-TRFS Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mito-TRFS1859102-62-7Fluorescent DyeParkinson'sHeLamitochondrialthioredoxinreductaseInhibitorinhibitorinhibit

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