2. Academic Validation
  3. 2-(2-Phenylethyl)chromone derivatives in artificial agarwood from Aquilaria sinensis

2-(2-Phenylethyl)chromone derivatives in artificial agarwood from Aquilaria sinensis

  • Fitoterapia. 2016 Apr:110:38-43. doi: 10.1016/j.fitote.2016.01.011.
Ge Liao 1,  Wen-Li Mei 2,  Wen-Hua Dong 2,  Wei Li 2,  Pei Wang 2,  Fan-Dong Kong 2,  Cui-Juan Gai 2,  Xi-Qiang Song 3,  Hao-Fu Dai 4
Affiliations

Affiliations

  • 1 College of Horticulture and Landscape Architecture, Hainan University, Haikou 570228, PR China.
  • 2 Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
  • 3 College of Horticulture and Landscape Architecture, Hainan University, Haikou 570228, PR China. Electronic address: [email protected].
  • 4 Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China. Electronic address: [email protected].
PMID: 26784520 DOI: 10.1016/j.fitote.2016.01.011
Abstract

Seven new 2-(2-phenylethyl)chromone derivatives (1-7) including a chlorinated one (4), together with eight known ones (8-15), were isolated from the EtOAc extract of artificial agarwood originating from Aquilaria sinensis (Lour.) Gilg. All structures including the absolute configurations were unambiguously elucidated by spectroscopic (NMR, UV, IR, MS) methods, Mosher's method, and comparison with reported data in the literatures. Among those, compounds 8, 12, and 14 exhibited significant inhibition against α-glucosidase in vitro with IC50 values of 0.15, 0.05, and 0.09 mM, respectively (with acarbose as the positive control; IC50: 0.98 mM). In addition, compounds 3, 9, 11, and 14 showed weak inhibitory activity against AChE; and compounds 12 and 13 displayed weak cytotoxicity against human gastric cell line (SGC-7901) among three types of tested human Cancer cell lines (BEL-7402, K562, and SGC-7901).

Keywords

2-(2-Phenylethyl)chromone; Agarwood; Aquilaria sinensis; Biological activity.

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