2-(2-Phenylethyl)chromone
Based on 1 Customer Validation
2-(2-Phenylethyl) chromone (Flidersiachromone) is a chromone derivative and antioxidant. 2-(2-Phenylethyl) chromone scavenges ABTS·+ free radicals, and its derivatives exhibit diverse activities including anti-inflammatory, neuroprotective, anti-tumor, and α-glucosidase inhibitory effects. 2-(2-Phenylethyl) chromone is applicable to experimental research in fields such as inflammation-related diseases, tumors, and neurodegenerative diseases.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 61828-53-3
- 分子式: C17H14O2
- 分子量:250.29
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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α‑glucosidase |
Derivatives of 2-(2-Phenylethyl) chromone exhibit α-glucosidase inhibitory activity. Among them, compound 8, 12 and 14 have IC50 values of 0.15 mM, 0.05 mM and 0.09 mM against α-glucosidase, respectively (the positive control Acarbose (HY-B0089) has an IC50 of 0.98 mM)[2].
Derivatives of 2-(2-Phenylethyl) chromone (12.5-100 μM; 48 h) exhibit neuroprotective activity, among which compound 1 (Aquisinenin G) protects human neuroblastoma SH-SY5Y cells against H2O2-induced apoptosis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells
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Concentration:12.5, 25, 50, 100 μM
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Incubation Time:48 h
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Result:Achieved improvements of 62.54 +6.39%, 66.84+8.59%, 67.42+5.38%, 75.04+8.59%, respectively.
化学情報
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CAS 番号 61828-53-3
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性状 Solid
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分子量 250.29
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分子式 C17H14O2
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Color Off-white to gray
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SMILES
O=C1C=C(CCC2=CC=CC=C2)OC3=CC=CC=C13
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別名
Flidersiachromone
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 100 mg/mL (399.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.99 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.99 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Liao G, et al. 2-(2-Phenylethyl)chromone derivatives in artificial agarwood from Aquilaria sinensis. Fitoterapia. 2016 Apr;110:38-43. [Content Brief]
[2]. Xu GH, et al. 2-(2-Phenylethyl)chromone-Sesquiterpene Hybrids from Agarwood of Aquilaria sinensis: Characterization and Biological Activity Evaluation. Molecules. 2025 Apr 29;30(9):1984. [Content Brief]
[3]. Li CG, et al. Antioxidative 2-(2-phenylethyl)chromones in Chinese eaglewood from Aquilaria sinensis. J Asian Nat Prod Res. 2020 Jul;22(7):639-646. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9954 mL | 19.9768 mL | 39.9537 mL | 99.8841 mL |
| 5 mM | 0.7991 mL | 3.9954 mL | 7.9907 mL | 19.9768 mL | |
| 10 mM | 0.3995 mL | 1.9977 mL | 3.9954 mL | 9.9884 mL | |
| 15 mM | 0.2664 mL | 1.3318 mL | 2.6636 mL | 6.6589 mL | |
| 20 mM | 0.1998 mL | 0.9988 mL | 1.9977 mL | 4.9942 mL | |
| 25 mM | 0.1598 mL | 0.7991 mL | 1.5981 mL | 3.9954 mL | |
| 30 mM | 0.1332 mL | 0.6659 mL | 1.3318 mL | 3.3295 mL | |
| 40 mM | 0.0999 mL | 0.4994 mL | 0.9988 mL | 2.4971 mL | |
| 50 mM | 0.0799 mL | 0.3995 mL | 0.7991 mL | 1.9977 mL | |
| 60 mM | 0.0666 mL | 0.3329 mL | 0.6659 mL | 1.6647 mL | |
| 80 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 1.2486 mL | |
| 100 mM | 0.0400 mL | 0.1998 mL | 0.3995 mL | 0.9988 mL |
2-(2-Phenylethyl)chromone 関連分類
HY-N8220 関連分類
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