2. Academic Validation
  3. Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs)

Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs)

  • Int J Mol Sci. 2016 Feb 2;17(2):194. doi: 10.3390/ijms17020194.
Houzong Yao 1,  Feng Jiang 2 3,  Aiping Lu 4,  Ge Zhang 5
Affiliations

Affiliations

  • 1 Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. [email protected].
  • 2 Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. [email protected].
  • 3 Faculty of Materials Science and Chemical Engineering, the State Key Laboratory Base of Novel Functional Materials and Preparation Science, Ningbo University, Ningbo 315211, Zhejiang, China. [email protected].
  • 4 Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. [email protected].
  • 5 Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. [email protected].
PMID: 26848651 DOI: 10.3390/ijms17020194
Abstract

Antibody-drug conjugates (ADCs) have become a promising targeted therapy strategy that combines the specificity, favorable pharmacokinetics and biodistributions of antibodies with the destructive potential of highly potent drugs. One of the biggest challenges in the development of ADCs is the application of suitable linkers for conjugating drugs to antibodies. Recently, the design and synthesis of linkers are making great progress. In this review, we present the methods that are currently used to synthesize antibody-drug conjugates by using thiols, amines, alcohols, aldehydes and azides.

Keywords

antibody-drug conjugates (ADCs); drugs; linkers; monoclonal antibodies (mAbs); targeted therapy.

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