2. Academic Validation
  3. Leucine-derived cyanoglucosides from the aerial parts of Sorbaria sorbifolia (L.) A. Braun

Leucine-derived cyanoglucosides from the aerial parts of Sorbaria sorbifolia (L.) A. Braun

  • Fitoterapia. 2016 Jun:111:102-8. doi: 10.1016/j.fitote.2016.03.015.
Gui-Wu Qu 1,  Chang-Jing Wu 2,  Shi-Zhou Gong 2,  Ze-Ping Xie 3,  Chang-Jun Lv 4
Affiliations

Affiliations

  • 1 School of Gerontology, Binzhou Medical University, Yantai 264003, PR China; Marine and Natural Drugs Research Center, Shandong, International Biotechnology Park Development Co., Ltd, Yantai 264670, PR China.
  • 2 Marine and Natural Drugs Research Center, Shandong, International Biotechnology Park Development Co., Ltd, Yantai 264670, PR China.
  • 3 Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai 264003, PR China.
  • 4 School of Gerontology, Binzhou Medical University, Yantai 264003, PR China. Electronic address: [email protected].
PMID: 27060709 DOI: 10.1016/j.fitote.2016.03.015
Abstract

Six new cyanoglucosides, 2S-cardiospermin-5-benzoate (1), 2R-cardiospermin-5-p-hydroxybenzoate (2), 2S-cardiospermin-5-cis-p-coumarate (3), isocardiospermin-5-p-hydroxybenzoate (4), sutherlandin-5-p-hydroxybenzoate (5), and sutherlandin-5-cis-p-coumarate (6), together with 17 known compounds were isolated from Sorbaria sorbifolia. The structures of the new compounds were elucidated by extensive spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS and ECD experiments. The biosynthetic relationship of 1-9 was also discussed. The cyanoglucosides (1-9) and 15 exhibited moderate inhibitory effect on nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS).

Keywords

Anti-inflammation activity; Cardiospermin; Cyanoglucosides; Sorbaria sorbifolia; Sutherlandin.

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