2. Academic Validation
  3. Kaurane and abietane diterpenoids from the roots of Tripterygium wilfordii and their cytotoxic evaluation

Kaurane and abietane diterpenoids from the roots of Tripterygium wilfordii and their cytotoxic evaluation

  • Bioorg Med Chem Lett. 2016 Jun 15;26(12):2942-2946. doi: 10.1016/j.bmcl.2016.04.026.
Chang Gao 1,  Di Wang 1,  Yan Zhang 2,  Xiao-Xiao Huang 3,  Shao-Jiang Song 4
Affiliations

Affiliations

  • 1 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 11016, PR China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, PR China.
  • 2 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, PR China.
  • 3 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 11016, PR China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, PR China. Electronic address: [email protected].
  • 4 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 11016, PR China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, PR China. Electronic address: [email protected].
PMID: 27133593 DOI: 10.1016/j.bmcl.2016.04.026
Abstract

Kaurane Diterpenoids and abietane Diterpenoids are the major anti-tumor components in Tripterygium wilfordii (Celastraceae). Extraction of Tripterygium wilfordii afforded a new diterpenoid and twenty known Diterpenoids belonging to the abietane and ent-kaurane families. The structures of all these compounds were characterized by spectroscopic techniques. All compounds were evaluated using the MTT method for in vitro cytotoxicity against six human Cancer cell lines (HepG2, Hep3B, Bcap37, U251, MCF-7 and A549). Compounds 7 and 12 exhibited marked cytotoxicity against a six cell lines with IC50 values in the range 5.10-23.30μM. The structure-cytotoxic activity relationships of these Diterpenoids are also discussed.

Keywords

Aromatic abietane; Celastraceae; Cytotoxicity; Diterpenoids; Ent-kaurane; Tripterygium wilfordii.

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