2. Academic Validation
  3. Isolation and structural elucidation of a new tadalafil analogue in health supplements: bisprenortadalafil

Isolation and structural elucidation of a new tadalafil analogue in health supplements: bisprenortadalafil

  • Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Jun;33(6):945-52. doi: 10.1080/19440049.2016.1179134.
Ji Hyun Lee 1,  Han Na Park 1,  Bogonda Ganganna 2,  Ji Hye Jeong 1,  Sung-Kwan Park 1,  Jongkook Lee 2,  Sun Young Baek 1
Affiliations

Affiliations

  • 1 a Advanced Analysis Team, Toxicological Evaluation and Research Department , National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety , Cheongju-si , Korea.
  • 2 b College of Pharmacy , Kangwon National University , Chuncheon , Korea.
PMID: 27167568 DOI: 10.1080/19440049.2016.1179134
Abstract

A new tadalafil analogue was found, along with nortadalafil, using HPLC-DAD during the inspection of a health product sold without official approval. The analogue was separated using a semi-preparative HPLC system and its structure was determined by a combination of mass spectrometry and NMR spectroscopy. The compound was identified as a tadalafil analogue in which the N-methyl group of tadalafil was replaced with a tadalafil precursor moiety. Nuclear Overhauser effect spectroscopy experiments suggested a cis-relationship between the substituents on a piperidine ring in the tadalafil moiety.

Keywords

PDE-5 inhibitor; Tadalafil analogue; bisprenortadalafil; dietary supplement; nortadalafil.

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