2. Academic Validation
  3. Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells

Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells

  • Bioorg Med Chem Lett. 2016 Jul 15;26(14):3351-3354. doi: 10.1016/j.bmcl.2016.05.035.
Jin Woo Lee 1,  Qinghao Jin 1,  Hari Jang 1,  Dongho Lee 2,  Sang Bae Han 1,  Youngsoo Kim 1,  Jin Tae Hong 1,  Mi Kyeong Lee 1,  Bang Yeon Hwang 3
Affiliations

Affiliations

  • 1 College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea.
  • 2 College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
  • 3 College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea. Electronic address: [email protected].
PMID: 27246615 DOI: 10.1016/j.bmcl.2016.05.035
Abstract

Bioactivity-guided fractionation of the MeOH extract from the roots of Euphorbia kansui resulted in the isolation of two new jatrophane-type Diterpenoids, kanesulones A (1) and B (2), together with six known jatrophane-type Diterpenoids (3-8) and ten known ingenane-type Diterpenoids (9-18). Their chemical structures were elucidated on the basis of spectroscopic data interpretation, especially 1D and 2D NMR such as HMQC, HMBC, COSY and NOESY, and HRESIMS data as well as CD analysis. Compounds 1-8 and 11-18 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values ranging from 0.7 to 46.5μM in RAW 264.7 macrophages.

Keywords

Diterpenoid; Euphorbia kansui; Euphorbiaceae; Nitric oxide production inhibitor.

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