2. Academic Validation
  3. Syntheses and photodynamic activity of some glucose-conjugated BODIPY dyes

Syntheses and photodynamic activity of some glucose-conjugated BODIPY dyes

  • Eur J Med Chem. 2016 Oct 21:122:352-365. doi: 10.1016/j.ejmech.2016.06.050.
Neelam Shivran 1,  Mrityunjay Tyagi 1,  Soumyaditya Mula 1,  Pooja Gupta 1,  Bhaskar Saha 1,  Birija S Patro 1,  Subrata Chattopadhyay 2
Affiliations

Affiliations

  • 1 Bio-Organic Division, Bhabha Atomic Resesarch Centre, Mumbai 400 085, India.
  • 2 Bio-Organic Division, Bhabha Atomic Resesarch Centre, Mumbai 400 085, India. Electronic address: [email protected].
PMID: 27393947 DOI: 10.1016/j.ejmech.2016.06.050
Abstract

The syntheses of three water-soluble glucose-conjugated BODIPY dyes with different wavelength emissions and studies of their photodynamic therapeutic (PDT) action on human lung Cancer A549 cell line are disclosed. Amongst the chosen compounds, the BODIPY dye 4 possessing a glycosylated styryl moiety at the C-3 position showed best PDT property against the A549 cell line. In particular, it induced reactive oxygen species-mediated Caspase-8/caspase-3-dependent Apoptosis as revealed from the increased sub G1 cell population and changes in cell morphology. These results along with its localization in the endoplasmic reticulum, as revealed by confocal microscopy suggested that mitochondria may not be directly involved in the photo-cytotoxicity of 4. Compound 4 did not induce any dark toxicity to the A549 cells, and was non-toxic to normal lung cells.

Keywords

Apoptosis; BODIPY dyes; Lung cancer; Photodynamic property.

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