Pyrromethene 567
Pyrromethene 567 is a commercially available BODIPY dye with a photodynamic cytotoxicity IC50 of 6.8 ± 1.8 μM.Pyrromethene 567 shows cytoplasmic localization and limited cellular uptake in cancer cells.Pyrromethene 567 can be used for the research of lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 131083-16-4
- Formula: C18H25BF2N2
- Molecular Weight:318.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
6.8 μM
Compound: PM567
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Photocytotoxicity against human A549 cells assessed as decrease in cell viability preincubated for 1 hr followed by 0.77 mW/cm2 white light irradiation for 80 mins measured after 24 hrs by MTT assay
Photocytotoxicity against human A549 cells assessed as decrease in cell viability preincubated for 1 hr followed by 0.77 mW/cm2 white light irradiation for 80 mins measured after 24 hrs by MTT assay
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[PMID: 27393947] |
Pyrromethene 567 exerts photodynamic cytotoxicity against human lung carcinoma A549 cells with an IC50 of 6.8 μM and shows no dark toxicity at concentrations up to 200 μM[1].
Pyrromethene 567 (1 μM; 0.5 h) localizes to the cytoplasm of human lung carcinoma A549 cells but exhibits lower cellular uptake than other tested BODIPY dyes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human lung carcinoma A549 cells
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Concentration:6.8 μM (photodynamic cytotoxicity); up to 200 μM (dark toxicity)
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Incubation Time:80 min photo-exposure, 24 h post-exposure incubation (photodynamic cytotoxicity); 48 h (dark toxicity)
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Result:Exhibited photodynamic cytotoxicity against A549 cells with a growth inhibitory IC50 value of 6.8 μM.
Showed no dark toxicity at concentrations up to 200 μM.
Chemical Information
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CAS No. 131083-16-4
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Molecular Weight 318.21
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Formula C18H25BF2N2
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SMILES
[F-][B+3]1([N]2=C(C)C(CC)=C(C)C2=C(C)C3=C(C)C(CC)=C(C)[N-]31)[F-]
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Synonyms
PM567
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pyrromethene 567 Related Classifications
HY-W248121 Related Classifications
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