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  4. Pyrromethene 567

Pyrromethene 567 is a commercially available BODIPY dye with a photodynamic cytotoxicity IC50 of 6.8 ± 1.8 μM.Pyrromethene 567 shows cytoplasmic localization and limited cellular uptake in cancer cells.Pyrromethene 567 can be used for the research of lung cancer.

For research use only. We do not sell to patients.

Pyrromethene 567

Pyrromethene 567 Chemical Structure

CAS No. : 131083-16-4

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Description

Pyrromethene 567 is a commercially available BODIPY dye with a photodynamic cytotoxicity IC50 of 6.8 ± 1.8 μM.Pyrromethene 567 shows cytoplasmic localization and limited cellular uptake in cancer cells.Pyrromethene 567 can be used for the research of lung cancer[1].

In Vitro

Pyrromethene 567 exerts photodynamic cytotoxicity against human lung carcinoma A549 cells with an IC50 of 6.8 μM and shows no dark toxicity at concentrations up to 200 μM[1].
Pyrromethene 567 (1 μM; 0.5 h) localizes to the cytoplasm of human lung carcinoma A549 cells but exhibits lower cellular uptake than other tested BODIPY dyes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyrromethene 567 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: human lung carcinoma A549 cells
Concentration: 6.8 μM (photodynamic cytotoxicity); up to 200 μM (dark toxicity)
Incubation Time: 80 min photo-exposure, 24 h post-exposure incubation (photodynamic cytotoxicity); 48 h (dark toxicity)
Result: Exhibited photodynamic cytotoxicity against A549 cells with a growth inhibitory IC50 value of 6.8 μM.
Showed no dark toxicity at concentrations up to 200 μM.
Molecular Weight

318.21

Formula

C18H25BF2N2
CAS No.
SMILES

[F-][B+3]1([N]2=C(C)C(CC)=C(C)C2=C(C)C3=C(C)C(CC)=C(C)[N-]31)[F-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pyrromethene 567 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyrromethene 567131083-16-4PM567Pyrromethene567Pyrromethene-567PM 567PM-567Fluorescent Dyehuman lung carcinoma A549 cellscytoplasmlung cancerBODIPY dyecancer cellsInhibitorinhibitorinhibit

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