Pyrromethene 567
Pyrromethene 567 is a commercially available BODIPY dye with a photodynamic cytotoxicity IC50 of 6.8 ± 1.8 μM.Pyrromethene 567 shows cytoplasmic localization and limited cellular uptake in cancer cells.Pyrromethene 567 can be used for the research of lung cancer.
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- CAS No.: 131083-16-4
- Formule: C18H25BF2N2
- Masse moléculaire:318.21
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
6.8 μM
Compound: PM567
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Photocytotoxicity against human A549 cells assessed as decrease in cell viability preincubated for 1 hr followed by 0.77 mW/cm2 white light irradiation for 80 mins measured after 24 hrs by MTT assay
Photocytotoxicity against human A549 cells assessed as decrease in cell viability preincubated for 1 hr followed by 0.77 mW/cm2 white light irradiation for 80 mins measured after 24 hrs by MTT assay
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[PMID: 27393947] |
In Vitro
Pyrromethene 567 exerts photodynamic cytotoxicity against human lung carcinoma A549 cells with an IC50 of 6.8 μM and shows no dark toxicity at concentrations up to 200 μM[1].
Pyrromethene 567 (1 μM; 0.5 h) localizes to the cytoplasm of human lung carcinoma A549 cells but exhibits lower cellular uptake than other tested BODIPY dyes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human lung carcinoma A549 cells
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Concentration:6.8 μM (photodynamic cytotoxicity); up to 200 μM (dark toxicity)
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Incubation Time:80 min photo-exposure, 24 h post-exposure incubation (photodynamic cytotoxicity); 48 h (dark toxicity)
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Result:Exhibited photodynamic cytotoxicity against A549 cells with a growth inhibitory IC50 value of 6.8 μM.
Showed no dark toxicity at concentrations up to 200 μM.
Chemical Information
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CAS No. 131083-16-4
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Masse moléculaire 318.21
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Formule C18H25BF2N2
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SMILES
[F-][B+3]1([N]2=C(C)C(CC)=C(C)C2=C(C)C3=C(C)C(CC)=C(C)[N-]31)[F-]
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Synonyms
PM567
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pyrromethene 567 Related Classifications
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