2. Academic Validation
  3. Metabolites with Gram-negative bacteria quorum sensing inhibitory activity from the marine animal endogenic fungus Penicillium sp. SCS-KFD08

Metabolites with Gram-negative bacteria quorum sensing inhibitory activity from the marine animal endogenic fungus Penicillium sp. SCS-KFD08

  • Arch Pharm Res. 2017 Jan;40(1):25-31. doi: 10.1007/s12272-016-0844-3.
Fan Dong Kong 1,  Li Man Zhou 1,  Qing Yun Ma 1,  Sheng Zhuo Huang 1,  Pei Wang 1,  Hao Fu Dai 1,  You Xing Zhao 2
Affiliations

Affiliations

  • 1 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou, 571101, People's Republic of China.
  • 2 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou, 571101, People's Republic of China. [email protected].
PMID: 27709333 DOI: 10.1007/s12272-016-0844-3
Abstract

Three new compounds named penicitor A, aculene E and penicitor B, as well as four known compounds, were isolated from the fermentation broth of Penicillium sp. SCS-KFD08 associated with a marine animal Sipunculus nudus from the Haikou bay of China. Their planar structures and absolute configurations were unambiguously elucidated by spectroscopic data, Mosher's method, CD spectrum analysis along with quantum ECD calculation. Among them, compounds 2-7 showed quorum sensing inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations.

Keywords

Marine fungus; Metabolites; Penicillium sp.; Quorum sensing inhibitory activity.

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