2. Academic Validation
  3. A new dimeric stilbene from the lianas of Gnetum parvifolium

A new dimeric stilbene from the lianas of Gnetum parvifolium

  • Nat Prod Res. 2017 Jul;31(13):1495-1500. doi: 10.1080/14786419.2017.1278591.
Li-Wen Tian 1,  Jun-Jiang Lv 2,  Yao Liu 1,  Lu-Yao Song 3,  Lian-Bing Hou 3,  Cheng Zhong 1,  Yang Xie 1
Affiliations

Affiliations

  • 1 a School of Pharmaceutical Sciences , Southern Medical University , Guangzhou , People's Republic of China.
  • 2 b Chemistry and Chemical Engineering college , Chongqing University , Chongqing , People's Republic of China.
  • 3 c Department of Pharmacy, Nangfang Hospital , Southern Medical University , Guangzhou , People's Republic of China.
PMID: 28081652 DOI: 10.1080/14786419.2017.1278591
Abstract

A new dimeric stilbene, gnetifolin P (1), was isolated from the lianas of Gnetum parvifolium, together with seven known compounds 2-8. The structure of compound 1 was determined by extensive NMR and HRESIMS data analyses, and quantum chemical calculations. All the compounds were evaluated for their anti-inflammatory activity. Compounds 1 and 6 inhibited the expression of IL-1β on LPS induced THP-1 cells with the inhibition rate of 35.78 and 64.67%, respectively, at concentration of 25 μg/mL.

Keywords

ECD calculation; Gnetum parvifolium; anti-inflammatory activity; dimeric stilbene.

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