2. Academic Validation
  3. Recent updates of carbapenem antibiotics

Recent updates of carbapenem antibiotics

  • Eur J Med Chem. 2017 May 5:131:185-195. doi: 10.1016/j.ejmech.2017.03.022.
Mohammed I El-Gamal 1,  Imen Brahim 2,  Noorhan Hisham 2,  Rand Aladdin 2,  Haneen Mohammed 2,  Amany Bahaaeldin 2
Affiliations

Affiliations

  • 1 College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt. Electronic address: [email protected].
  • 2 College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates.
PMID: 28324783 DOI: 10.1016/j.ejmech.2017.03.022
Abstract

Carbapenems are among the most commonly used and the most efficient Antibiotics since they are relatively resistant to hydrolysis by most β-lactamases, they target penicillin-binding proteins, and generally have broad-spectrum Antibacterial effect. In this review, we described the initial discovery and development of carbapenems, chemical characteristics, in vitro/in vivo activities, resistance studies, and clinical investigations for traditional carbapenem Antibiotics in the market; imipenem-cilastatin, meropenem, ertapenem, doripenem, biapenem, panipenem/betamipron in addition to newer carbapenems such as razupenem, tebipenem, tomopenem, and sanfetrinem. We focused on the literature published from 2010 to 2016.

Keywords

Antibiotic resistance; Carbapenems; β-lactamases; β-lactams.

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