2. Academic Validation
  3. A novel group of sperm activating peptides from the sea urchin Glyptocidaris crenularis

A novel group of sperm activating peptides from the sea urchin Glyptocidaris crenularis

  • Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;90(2):305-11. doi: 10.1016/0742-8413(88)90003-5.
N Suzuki 1,  K Yoshino,  M Kurita,  K Nomura,  M Yamaguchi
Affiliations

Affiliation

  • 1 Noto Marine Laboratory, Kanazawa University, Ishikawa, Japan.
PMID: 2902991 DOI: 10.1016/0742-8413(88)90003-5
Abstract

1. Six new sperm activating Peptides were purified from the egg jelly of the sea urchin Glyptocidaris crenularis and their amino acid sequences were determined as follows: Ser-Ala-Lys-Leu-Cys-Pro-Gly-Gly-Asn-Cys-Val, Lys-Leu-Cys-Pro-Gly-Gly-Asn-Cys-Val, Leu-Cys-Pro-Gly-Gly-Asn-Cys-Val, Ser-Phe-Lys-Leu-Cys-Pro-Gly-Gly-Gln-Cys-Val, Lys-Leu-Cys-Pro-Gly-Gly-Gln-Cys-Val and Leu-Cys-Pro-Gly-Gly-Gln-Cys-Val. 2. The Peptides were specific for G. crenularis spermatozoa and caused significant increases of sperm respiration rates and sperm cyclic nucleotide concentrations at concentrations as low as 10(-10) M. 3. The addition of the Peptides to intact spermatozoa resulted in the change of the apparent mol. wt of a sperm protein from 195,000 to 200,000.

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