2. Academic Validation
  3. Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats

Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats

  • Bull Exp Biol Med. 2017 Dec;164(2):140-143. doi: 10.1007/s10517-017-3943-3.
L А Sever'yanova 1,  M E Dolgintsev 2
Affiliations

Affiliations

  • 1 Department of Pathophysiology, Kursk State Medical University, Kursk, Russia. [email protected].
  • 2 Department of Pathophysiology, Kursk State Medical University, Kursk, Russia.
PMID: 29181666 DOI: 10.1007/s10517-017-3943-3
Abstract

We studied the effect of Gly-His -Lys tripeptide administered intraperitoneally in doses of 5, 15, 50 and 150 μg/kg on pain-induced aggressive-defensive behavior. A foot-shock model of aggression in rats grouped in pairs in an electrified chamber was used. Analgesic and antiaggresiogenic effects of the peptide were demonstrated. It was found the L-lysine residue plays the key role in these effects, because they were observed under the influence of L-lysine administration in doses close to its equimolar content in the studied tripeptide.

Keywords

aggressive-defensive behavior; amino acids; pain; regulatory peptides.

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