Gly-His-Lys acetate
Based on 1 Customer Validation
Gly-His-Lys acetate is a natural, circulating regulatory and antimicrobial tripeptide derived from extracellular matrix proteins. Gly-His-Lys acetate binds Cu2+ to support copper enzyme activation, antioxidant processes, cellular bioenergetics, and the synthesis of elastin, collagen and catecholamines. Gly-His-Lys acetate regulates cell growth, differentiation and tissue repair, and exerts regenerative, anxiolytic, anti-inflammatory, analgesic and immunosuppressive activities. Gly-His-Lys acetate induces liver degenerative changes. Gly-His-Lys acetate can be used for the research of infections, anxiety, pain-related behaviors and immune-associated liver diseases.
For research use only. We do not sell to patients.
- Purity: 99.68%
- CAS No.: 72957-37-0
- Formula: C16H28N6O6
- Molecular Weight:400.43
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Gly-His-Lys acetate display potent antimicrobial activity against Staphylococcus aureus spp., Escherichia coli spp., Pseudomonas aeruginosa spp. and Candida albicans spp., and exert rapid bactericidal and fungicidal effects[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gly-His-Lys (5-150 μg/kg; i.p.; single dose, 12 min pre-stimulation) acetate exhibits dose-dependent analgesic and antiaggresogenic effects in rats with pain-induced aggressive-defensive behavior[3].
Gly-His-Lys (0.5-450 mg/kg; i.p.; daily; 10 days) acetate stimulates hepatocyte mitotic index in a dose-independent manner at ≥ 1.5 mg/kg and exerts a dose-dependent suppression of humoral immune response in CBA mice[4].
Gly-His-Lys (0.5-450 mg/kg; i.p.; daily; 10 days) acetate exerts a dose-dependent suppression of delayed-type hypersensitivity in Wistar rats at ≥ 1.5 mg/kg[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar (male, 180-220 g)[2]
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Dosage:0.5 μg/kg; 5 μg/kg; 50 μg/kg
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Administration:i.p.; single dose
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Result:Increased time spent in open arms, entries into open arms, and time on the central platform, while decreasing time in closed arms at 0.5 and 5 μg/kg; at 50 μg/kg, it still elevated central platform time and closed-arm entries but showed no significant difference in open-arm time versus control.
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Animal Model:Wistar rats (male, 180-200 g)[3]
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Dosage:5 μg/kg; 15 μg/kg; 50 μg/kg; 150 μg/kg
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Administration:i.p.; single dose, 12 min pre-stimulation
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Result:Increased flinching, vocalization, rearing, running, and fighting thresholds while reducing fight frequency at 5, 15, 50, and 150 μg/kg; the effects were most prominent at 150 μg/kg.
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Animal Model:CBA (weight 20-25 g)[4]
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Dosage:0.5 mg/kg; 1.5 mg/kg; 5 mg/kg; 50 mg/kg; 150 mg/kg; 450 mg/kg
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Administration:i.p.; daily; 10 days
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Result:Increased hepatocyte mitotic index significantly at 1.5-450 mg/kg with no obvious dose dependence, dose-dependently reduced antibody-producing spleen cell number, and induced liver degeneration at 150 mg/kg and 450 mg/kg with more severe lesions at 450 mg/kg.
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Animal Model:Wistar (weight 180-220 g)[4]
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Dosage:0.5 mg/kg; 1.5 mg/kg; 5 mg/kg; 50 mg/kg; 150 mg/kg; 450 mg/kg
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Administration:i.p.; daily; 10 days
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Result:Reduced the regional-versus-contralateral popliteal lymph node weight difference and nucleated cell count difference dose-dependently at 1.5-450 mg/kg, significantly inhibited delayed-type hypersensitivity, and induced obvious liver degeneration at 150 mg/kg and 450 mg/kg with more severe injury at 450 mg/kg.
Chemical Information
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CAS No. 72957-37-0
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Appearance Solid
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Molecular Weight 400.43
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Formula C16H28N6O6
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Color White to off-white
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SMILES
NCCCC[C@H](NC([C@@H](NC(CN)=O)CC1=CNC=N1)=O)C(O)=O.CC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
H2O : 100 mg/mL (249.73 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.4973 mL | 12.4866 mL | 24.9732 mL | 62.4329 mL |
| 5 mM | 0.4995 mL | 2.4973 mL | 4.9946 mL | 12.4866 mL | |
| 10 mM | 0.2497 mL | 1.2487 mL | 2.4973 mL | 6.2433 mL | |
| 15 mM | 0.1665 mL | 0.8324 mL | 1.6649 mL | 4.1622 mL | |
| 20 mM | 0.1249 mL | 0.6243 mL | 1.2487 mL | 3.1216 mL | |
| 25 mM | 0.0999 mL | 0.4995 mL | 0.9989 mL | 2.4973 mL | |
| 30 mM | 0.0832 mL | 0.4162 mL | 0.8324 mL | 2.0811 mL | |
| 40 mM | 0.0624 mL | 0.3122 mL | 0.6243 mL | 1.5608 mL | |
| 50 mM | 0.0499 mL | 0.2497 mL | 0.4995 mL | 1.2487 mL | |
| 60 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0405 mL | |
| 80 mM | 0.0312 mL | 0.1561 mL | 0.3122 mL | 0.7804 mL | |
| 100 mM | 0.0250 mL | 0.1249 mL | 0.2497 mL | 0.6243 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Gly-His-Lys acetate Related Classifications
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