72957-37-0
Chemical Structure
Gly-His-Lys acetate
- CAS No.: 72957-37-0
- Formula:C16H28N6O6
- Molecular Weight:400.43
IUPAC Name: glycyl-L-histidyl-L-lysine compound with acetic acid (1:1)
InChIKey: MGNUTAFMLGJBGV-ACMTZBLWSA-N
SMILES: NCCCC[C@H](NC([C@@H](NC(CN)=O)CC1=CNC=N1)=O)C(O)=O.CC(O)=O
Biological Activity: Gly-His-Lys acetate is a natural, circulating regulatory and antimicrobial tripeptide derived from extracellular matrix proteins. Gly-His-Lys acetate binds Cu2+ to support copper enzyme activation, antioxidant processes, cellular bioenergetics, and the synthesis of elastin, collagen and catecholamines. Gly-His-Lys acetate regulates cell growth, differentiation and tissue repair, and exerts regenerative, anxiolytic, anti-inflammatory, analgesic and immunosuppressive activities. Gly-His-Lys acetate induces liver degenerative changes. Gly-His-Lys acetate can be used for the research of infections, anxiety, pain-related behaviors and immune-associated liver diseases[1][2][3][4].
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Gly-His-Lys acetate | 99.68% | Gly-His-Lys acetate is a natural, circulating regulatory and antimicrobial tripeptide derived from extracellular matrix proteins. Gly-His-Lys acetate binds Cu2+ to support copper enzyme activation, antioxidant processes, cellular bioenergetics, and the synthesis of elastin, collagen and catecholamines. Gly-His-Lys acetate regulates cell growth, differentiation and tissue repair, and exerts regenerative, anxiolytic, anti-inflammatory, analgesic and immunosuppressive activities. Gly-His-Lys acetate induces liver degenerative changes. Gly-His-Lys acetate can be used for the research of infections, anxiety, pain-related behaviors and immune-associated liver diseases. | ||||||||||||||||||||
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- [1]. Kukowska M, et al. In vitro studies of antimicrobial activity of Gly-His-Lys conjugates as potential and promising candidates for therapeutics in skin and tissue infections. Bioorg Med Chem Lett. 2015;25(3):542-546.
- [2]. Bobyntsev II, et al. Anxiolytic Effects of Gly-His-Lys Peptide and Its Analogs. Bull Exp Biol Med. 2015;158(6).
- [3]. Sever'yanova LА, et al. Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats. Bull Exp Biol Med. 2017 Dec;164(2):140-143. [Content Brief]
- [4]. Smakhtin MY, et al. Tripeptide Gly-His-Lys is a Hepatotropic Immunosuppressor. Bull Exp Biol Med. 2002;133(6):586.
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