2. Academic Validation
  3. A new coumarin from stem bark of Calophyllum wallichianum

A new coumarin from stem bark of Calophyllum wallichianum

  • Nat Prod Res. 2018 Nov;32(21):2565-2570. doi: 10.1080/14786419.2018.1428588.
Keng Hong Tee 1,  Gwendoline Cheng Lian Ee 1,  Intan Safinar Ismail 1 2,  Thiruventhan Karunakaran 1,  Soek Sin Teh 3,  Vivien Yi Mian Jong 4,  Siti Mariam Mohd Nor 1
Affiliations

Affiliations

  • 1 a Faculty of Science, Department of Chemistry , Universiti Putra Malaysia , Serdang , Malaysia.
  • 2 b Laboratory of Natural Products, Institute of Bioscience , Universiti Putra Malaysia , Serdang , Malaysia.
  • 3 c Energy and Environment Unit, Engineering & Processing Division, Malaysian Palm Oil Board , Kajang , Malaysia.
  • 4 d Centre of Applied Science Studies , Universiti Teknologi Mara , Kuching , Malaysia.
PMID: 29355031 DOI: 10.1080/14786419.2018.1428588
Abstract

A phytochemical study carried out on the plant, Calophyllum wallichianum has led to the isolation of a new coumarin, wallimarin T (1) and a known coumarin, calanolide E (2) along with two common Triterpenes, friedelin (3) and stigmasterol (4). The structures of these compounds were elucidated with the aid of spectroscopic analyses such as FT-IR, GC-MS, and NMR. MIC assay against the Bacillus bacteria were conducted on the extracts and this gave MIC values ranging from 0.313 to 1.25 mg/mL. Compound 2 was weakly inhibitory towards the Bacilli strains with MIC values ranging from 0.25-0.50 mg/mL. Wallimarin T (1) was not active towards all four bacteria. Overall, the extracts exhibited weak bactericidal properties whereas compound 2 was not bactericidal on the tested bacteria. The hexane and chloroform extracts of the plant were found to be inhibitors to the growth of Bacillus megaterium, Bacillus cereus, Bacillus pumilus and Bacillus subtilis.

Keywords

Calophyllum wallichianum; anti-bacterial; coumarin.

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