2. Academic Validation
  3. Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1

Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1

  • Biochem Biophys Res Commun. 2018 May 15;499(3):681-687. doi: 10.1016/j.bbrc.2018.03.212.
Masafumi Hidaka 1,  Keita Kosaka 1,  Saori Tsushima 1,  Chiyoko Uchida 2,  Katsuhiko Takahashi 3,  Noriko Takahashi 4,  Masayoshi Tsubuki 5,  Yukihiko Hara 6,  Takafumi Uchida 7
Affiliations

Affiliations

  • 1 Molecular Enzymology, Department of Molecular Cell Science, Graduate School of Agricultural Science, Tohoku University, 468-1 Aoba, Aramaki, Aoba, Sendai, Miyagi, 980-0845, Japan.
  • 2 Department of Human Development and Culture, Fukushima University, Fukushima, Fukushima, 960-1296, Japan.
  • 3 Laboratory of Biochemistry, Hoshi University, 2-4-41, Ebara, Shinagawa, Tokyo, 142-8501, Japan.
  • 4 Laboratory of Bioorganic Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo, 142-8501, Japan.
  • 5 Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2-4-41, Ebara, Shinagawa, Tokyo, 142-8501, Japan.
  • 6 Tea Solutions, Hara Office Inc., 1-18-15-510, Taihei, Sumida-Ku, Tokyo 130-0012, Japan.
  • 7 Molecular Enzymology, Department of Molecular Cell Science, Graduate School of Agricultural Science, Tohoku University, 468-1 Aoba, Aramaki, Aoba, Sendai, Miyagi, 980-0845, Japan. Electronic address: [email protected].
PMID: 29608894 DOI: 10.1016/j.bbrc.2018.03.212
Abstract

We searched for inhibitors against prolyl isomerase PIN1 in order to develop functional foods to prevent and cure various PIN1 related diseases such as Cancer, diabetes, Cardiovascular Disease, Alzheimers's disease, and so on. We created a polyphenol library consisting of ingredients in healthy foods and beverages, since Polyphenols like epigallocatechin gallate (EGCG) in green tea and 974B in brown algae had been identified as its PIN1 inhibitors. Several Polyphenols such as EGCG derivatives, caffeic acid derivatives and tannic acid inhibited PIN1 activity. These results provide a first step in development of the functional foods and beverage targeting PIN1 and its related diseases.

Keywords

Caffeic acid; EGCG; Food polyphenols; Pin1; Prolyl isomerase; Tannic acid.

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