2. Academic Validation
  3. β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities

β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities

  • Eur J Med Chem. 2018 Sep 5:157:622-656. doi: 10.1016/j.ejmech.2018.08.027.
Jiangkun Dai 1,  Wenjia Dan 1,  Uwe Schneider 2,  Junru Wang 3
Affiliations

Affiliations

  • 1 College of Chemistry & Pharmacy, Northwest A&F University, 22 Xinong Road, Yangling, 712100, Shaanxi, China.
  • 2 The University of Edinburgh, EaStCHEM School of Chemistry, The King's Buildings, David Brewster Road, Edinburgh, EH9 3FJ, UK. Electronic address: [email protected].
  • 3 College of Chemistry & Pharmacy, Northwest A&F University, 22 Xinong Road, Yangling, 712100, Shaanxi, China. Electronic address: [email protected].
PMID: 30125723 DOI: 10.1016/j.ejmech.2018.08.027
Abstract

β-Carboline Alkaloids are a family of natural and synthetic products with great structural diversity and outstanding biological activities. This review covers critically important developments in the field of β-carbolines, predominantly over the past decade (2006-2017.7). It is focused on both natural and synthetic monomers as well as dimers, and includes key information on occurrence, structural diversity, and biological activities. In the cases where sufficient information is available, structure-activity relationship (SAR) and mechanism of their biological activities were presented. In addition, innovative syntheses of the β-carboline core and potential future directions have been discussed.

Keywords

Biological activity; Dimer; Mechanism; Monomer; Occurrence; SAR; Structural diversity; β-Carboline.

Figures