2. Academic Validation
  3. Synthesis and antitumor activity of epothilone B

Synthesis and antitumor activity of epothilone B

  • Eur J Med Chem. 2018 Sep 5:157:925-934. doi: 10.1016/j.ejmech.2018.08.055.
Hao Cheng 1,  Hualiang Huang 2,  Gangliang Huang 3
Affiliations

Affiliations

  • 1 Chongqing Key Laboratory of Green Synthesis and Application, Active Carbohydrate Research Institute, Chongqing Normal University, Chongqing, 401331, China.
  • 2 School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan, 430073, China.
  • 3 Chongqing Key Laboratory of Green Synthesis and Application, Active Carbohydrate Research Institute, Chongqing Normal University, Chongqing, 401331, China. Electronic address: [email protected].
PMID: 30149324 DOI: 10.1016/j.ejmech.2018.08.055
Abstract

Epothilones are a class of 16-membered Macrolide compounds targeting microtubules. They have good Anticancer activity and their mechanism of action is similar to that of paclitaxel. Epothilones are also highly active against Cancer cells that are resistant to paclitaxel and other Anticancer drugs. They have good water solubility, simple structure, and are relatively easy to totally synthesize and or semi-synthesize. These results immediately attracted great interest and research enthusiasm from pharmaceutical companies and academia. Herein, the various synthetic methods of epothilone B and its Anticancer activity were summarized and analyzed.

Keywords

Antitumor activity; Epothilone B; Semi-synthesize; Targeting microtubules; Totally synthesize.

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