2. Academic Validation
  3. New nor-oleanane triterpenoids from the fruits of Stauntonia brachyanthera with potential anti-inflammation activity

New nor-oleanane triterpenoids from the fruits of Stauntonia brachyanthera with potential anti-inflammation activity

  • Nat Prod Res. 2020 Apr;34(7):915-922. doi: 10.1080/14786419.2018.1540478.
Jiaheng Li 1 2,  Kaicheng Du 3,  Dan Liu 3,  Dali Meng 3 4
Affiliations

Affiliations

  • 1 1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
  • 2 2Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing Shijitan Hospital Capital Medical University, Beijing, China.
  • 3 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
  • 4 Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing Shijitan Hospital Capital Medical University, Beijing, China.
PMID: 30600711 DOI: 10.1080/14786419.2018.1540478
Abstract

The continuing studies on the fruits of Stauntonia brachyanthera led to the isolations of 6 normal and nor-oleanane triterpenoids, including two new compounds, brachyantheoraside B10 (1) and brachyantheraside C1 (2). Compounds 1-3 showed inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 macrophages with the IC50 values of 27.04, 26.22, and 21.41 μM, respectively, which were all stronger than that of indomethacin. The study not only revealed a new type of nor-oleanane triterpenoids, but also confirmed the anti-inflammation abilities of three type nor-oleanane triterpenoids as the inhibitors of NO production.

Keywords

Anti-inflammation; Stauntonia brachyanthera; nor-oleanane triterpenoids.

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