Kalopanaxsaponin I
Kalopanaxsaponin I (Septemloside I) is an oleanane-type triterpenoid that exists in the fruits of Stauntonia brachyanthera. Kalopanaxsaponin I inhibits LPS (HY-D1056)-induced nitric oxide production in macrophages, with a IC50 of 80.25 μM.
For research use only. We do not sell to patients.
- CAS No.: 843668-13-3
- Formula: C69H112O34
- Molecular Weight:1485.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Kalopanaxsaponin I (6.25-100 μM; 24-25 h) inhibits LPS-induced nitric oxide production in RAW 264.7 macrophages with an IC50 of 80.25 μM, and exhibits no cytotoxicity at concentrations up to 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 macrophages
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Concentration:6.25, 12.5, 25, 50, 100 μM
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Incubation Time:24 h (NO inhibition assay); 25 h (MTT cytotoxicity assay)
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Result:Inhibited nitric oxide production by 5.47% at 6.25 μM, 11.76% at 12.5 μM, 25.83% at 25 μM, 34.12% at 50 μM, and 56.8% at 100 μM.
Reached an IC50 of 80.25 μM for nitric oxide inhibition.
Showed no cytotoxicity at all tested concentrations.
Chemical Information
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CAS No. 843668-13-3
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Molecular Weight 1485.61
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Formula C69H112O34
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SMILES
OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]3O)O)O)O[C@H]3OC([C@]45[C@](CC(C)(CC5)C)([H])C6=CC[C@@]([C@@]7([C@@]([C@@](C)([C@H](CC7)O[C@H]8[C@@H]([C@H]([C@H](CO8)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O[C@H]%10[C@@H]([C@H]([C@@H](CO%10)O[C@H]%11[C@@H]([C@H]([C@@H](CO%11)O)O)O)O)O)O)CO)([H])CC%12)C)([H])[C@]%12(C)[C@@]6(CC4)C)=O
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Synonyms
Septemloside I
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kalopanaxsaponin I Related Classifications
HY-N17961 Related Classifications
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