2. Natural Products
  3. Plants Terpenoids
  4. Lardizabalaceae Pentacyclic Triterpenoids
  5. Stauntonia cavalerieana Gagnep.
  6. Kalopanaxsaponin I

Kalopanaxsaponin I (Septemloside I) is an oleanane-type triterpenoid that exists in the fruits of Stauntonia brachyanthera. Kalopanaxsaponin I inhibits LPS (HY-D1056)-induced nitric oxide production in macrophages, with a IC50 of 80.25 μM.

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Kalopanaxsaponin I

Kalopanaxsaponin I Chemical Structure

CAS No. : 843668-13-3

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Kalopanaxsaponin I Related Antibodies

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Description

Kalopanaxsaponin I (Septemloside I) is an oleanane-type triterpenoid that exists in the fruits of Stauntonia brachyanthera. Kalopanaxsaponin I inhibits LPS (HY-D1056)-induced nitric oxide production in macrophages, with a IC50 of 80.25 μM[1].

In Vitro

Kalopanaxsaponin I (6.25-100 μM; 24-25 h) inhibits LPS-induced nitric oxide production in RAW 264.7 macrophages with an IC50 of 80.25 μM, and exhibits no cytotoxicity at concentrations up to 100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kalopanaxsaponin I Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: RAW 264.7 macrophages
Concentration: 6.25, 12.5, 25, 50, 100 μM
Incubation Time: 24 h (NO inhibition assay); 25 h (MTT cytotoxicity assay)
Result: Inhibited nitric oxide production by 5.47% at 6.25 μM, 11.76% at 12.5 μM, 25.83% at 25 μM, 34.12% at 50 μM, and 56.8% at 100 μM.
Reached an IC50 of 80.25 μM for nitric oxide inhibition.
Showed no cytotoxicity at all tested concentrations.
Molecular Weight

1485.61

Formula

C69H112O34
CAS No.
SMILES

OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]3O)O)O)O[C@H]3OC([C@]45[C@](CC(C)(CC5)C)([H])C6=CC[C@@]([C@@]7([C@@]([C@@](C)([C@H](CC7)O[C@H]8[C@@H]([C@H]([C@H](CO8)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O[C@H]%10[C@@H]([C@H]([C@@H](CO%10)O[C@H]%11[C@@H]([C@H]([C@@H](CO%11)O)O)O)O)O)O)CO)([H])CC%12)C)([H])[C@]%12(C)[C@@]6(CC4)C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Kalopanaxsaponin I Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kalopanaxsaponin I843668-13-3Septemloside IOthersmacrophagesoleanane triterpenoidnitric oxidelipopolysaccharideRAW 264.7 macrophagesStauntonia brachyantheraInhibitorinhibitorinhibit

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