2. Academic Validation
  3. Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it

Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it

  • Exp Biol Med (Maywood). 2019 Jan;244(1):1-12. doi: 10.1177/1535370218824538.
Constanze Buhrmann 1,  Mina Yazdi 1,  Bastian Popper 2,  Parviz Shayan 3,  Ajay Goel 4,  Bharat B Aggarwal 5,  Mehdi Shakibaei 1
Affiliations

Affiliations

  • 1 1 Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Faculty of Medicine, Ludwig-Maximilian-University Munich, Munich 80336, Germany.
  • 2 2 Biomedical Center, Ludwig-Maximilian-University Munich, Martinsried 82152, Germany.
  • 3 3 Department of Parasitology, Faculty of Veterinary Medicine, University of Tehran, Tehran 141556453, Iran.
  • 4 4 Center for Gastrointestinal Research; Baylor Scott & White Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75246, USA.
  • 5 5 Anti-Inflammation Research Institute, San Diego, CA 92126, USA.
PMID: 30661394 DOI: 10.1177/1535370218824538
Abstract

The mechanism by which Natural Products such as resveratrol suppresses TNF-β-promoted tumor cell proliferation, invasion, and colony formation is unknown. In this study, we explored for the first time the effect of resveratrol on the proinflammatory cytokine TNF-β-, compared to TNF-α-stimulated proliferative and pro-inflammatory signaling in HCT116 cells. Our findings suggest that expression of TNF-β and TNF-β-receptor, like TNF-α, can lead to activation of inflammatory transcription factor (NF-κB) and NF-κB-regulated gene biomarkers, which are involved in the promotion of Cancer proliferation, invasion, metastasis, and cell survival of tumor. Resveratrol can block TNF-β/TNF-β-receptor-induced activation of NF-κB, NF-κB-modulated gene products, and inhibition of Caspase-3 cleavage. These results highlight the therapeutic effect of resveratrol-mediated anti-tumor activity by multitargeting cellular signaling pathways.

Keywords

NF-κB; Resveratrol; TNF-β; colorectal cancer; proliferation.

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