2. Academic Validation
  3. A new sesquiterpenoid with cytotoxic and anti-inflammatory activity from the leaves of Datura metel L

A new sesquiterpenoid with cytotoxic and anti-inflammatory activity from the leaves of Datura metel L

  • Nat Prod Res. 2021 Feb;35(4):607-613. doi: 10.1080/14786419.2019.1590715.
Rui Guo 1 2,  Yan Liu 3,  Juan Pan 3,  Wei Guan 3,  Bing-You Yang 3,  Hai-Xue Kuang 3
Affiliations

Affiliations

  • 1 Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, Shanxi University of Chinese Medicine, Jinzhong, China.
  • 2 Hi-Tech Park, HKUST Shenzhen Research Institute, Nanshan, Shenzhen, China.
  • 3 Key Laboratory of Chinese Materia Medica Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, China.
PMID: 30919660 DOI: 10.1080/14786419.2019.1590715
Abstract

A new sesquiterpenoid glycoside, consisting of one vetispirane-type, dmetelisproside A (1), together with two known megastigmane sesquiterpenoids, citroside A (2) and staphylionoside D (3) were isolated from the leaves of Datura metel L. The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. All isolates were evaluated for cytotoxicity toward SGC-7901, Hepg2, HeLa, MCF-7, and MDA-MB-231 Cancer cell lines, and anti-inflammatory activity against nitric oxide (NO) in RAW 264.7 cells in vitro. Compounds 1 and 2 exhibited pronounced cytotoxicity against SGC-7901 and HeLa cells with IC50 values in the range of 21.43 to 29.51 μm. All three compounds displayed potential effects against NO production with IC50 values of 31.10, 34.25, and 44.31 μm, respectively. Thus, these isolated compounds in the leaves of Datura metel L were subjected to bioactivity substances for future studies on medicinal application.

Keywords

Leaves of Datura metel L.; anti-inflammatory activity; cytotoxicity; sesquiterpenoid; solanaceae.

Figures
Products