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  3. Synthesis of sulfamethoxazole and sulfabenzamide metal complexes; evaluation of their antibacterial activity

Synthesis of sulfamethoxazole and sulfabenzamide metal complexes; evaluation of their antibacterial activity

  • Eur J Med Chem. 2019 Jun 1;171:364-371. doi: 10.1016/j.ejmech.2019.03.002.
Shahnaz Rostamizadeh 1,  Zahra Daneshfar 2,  Hamid Moghimi 3
Affiliations

Affiliations

  • 1 Department of Chemistry, Faculty of Science, K. N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran. Electronic address: [email protected].
  • 2 Department of Chemistry, Faculty of Science, K. N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran.
  • 3 Department of Microbial Biotechnology, School of Biology, College of Science, University of Tehran, Enghelab Avenue, Tehran, 14155-6655, Iran. Electronic address: [email protected].
PMID: 30928708 DOI: 10.1016/j.ejmech.2019.03.002
Abstract

The present work describes the synthesis and spectroscopic characterization of ten different metal complexes of sulfabenzamide and sulfamethoxazole as ligands (M-SBZ, M-SMZ). Spectroscopic methods such as 1H NMR, UV-Vis spectroscopy analysis, FTIR and XRD confirmed the coordination of both ligands to metals through the nitrogen and oxygen atoms of the sulfonamide group. Both sulfabenzamide and sulfamethoxazole metal complexes were active against Gram-positive and negative Bacterial strains. Sulfamethoxazole complexes showed their MIC values from 0.125 to 2.000 g ml-1 and sulfabenzamide complexes exhibited related MIC values from 1.000 to 2.000 g ml-1. Finally Zn (II) sulfamethoxazole with an inexpensive and common metal displayed more activity than its free ligand drug.

Keywords

Antibacterial agents; Metal; Sulfabenzamide; Sulfamethoxazole; Sulfonamide metal complex.

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