2. Academic Validation
  3. Anti- Mycobacterium tuberculosis Terpenoids from Resina Commiphora

Anti- Mycobacterium tuberculosis Terpenoids from Resina Commiphora

  • Molecules. 2019 Apr 15;24(8):1475. doi: 10.3390/molecules24081475.
Chuan-Zhi Zhu 1 2,  Bin-Yuan Hu 3,  Jia-Wang Liu 4,  Yi Cai 5,  Xin-Chun Chen 6,  Da-Peng Qin 7,  Yong-Xian Cheng 8,  Zong-De Zhang 9
Affiliations

Affiliations

  • 1 Laboratory of Molecular Biology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China. [email protected].
  • 2 Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 3 Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 4 Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 5 Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 6 Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 7 Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 8 Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China. [email protected].
  • 9 Laboratory of Molecular Biology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China. [email protected].
PMID: 30991677 DOI: 10.3390/molecules24081475
Abstract

Four new compounds including two new sesquiterpenoid dimers, commiphoroids E (1) and F (2), a new triterpenoid (3), and a new sesquiterpenoid (4), along with three known Terpenoids (5-7) were isolated from Resina Commiphora, whose structures were identified by NMR spectra, HRESIMS, and X-ray diffraction analysis. Compounds 1 and 2 both bear an O-bridge ring and feature a plausible [4 + 2] Diels-Alder cycloaddition reaction. Antimycobacterial activities show that all the tested compounds (200 μM) could inhibit the growth of both sensitive and clinically multi-drug resistant (MDR) isolated strains. In addition, cellular toxicity of the isolates against human Cancer cells and THP-1 monocyte cells was examined.

Keywords

Resina Commiphora; anti-Mycobacterium tuberculosis; plant resins; terpenoids.

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