2. Academic Validation
  3. Chemical components from the twigs of Caesalpinia latisiliqua and their antiviral activity

Chemical components from the twigs of Caesalpinia latisiliqua and their antiviral activity

  • J Nat Med. 2020 Jan;74(1):26-33. doi: 10.1007/s11418-019-01335-2.
Mira Oh 1,  SeonJu Park 1,  Jae-Hyoung Song 2,  Hyun-Jeong Ko 2,  Seung Hyun Kim 3
Affiliations

Affiliations

  • 1 College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, South Korea.
  • 2 College of Pharmacy, Kangwon National University, Chuncheon, South Korea.
  • 3 College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, South Korea. [email protected].
PMID: 31243670 DOI: 10.1007/s11418-019-01335-2
Abstract

Three new compounds, (3S)-dihydrobonducellin 8-O-β-D-glucopyranoside (1), 3',5'-dimethoxy-jezonolid (2), and latisilinoid (3), along with 16 known compounds, were isolated from the twigs of Caesalpinia latisiliqua (Leguminosae). The known compounds were identified as Flavonoids, Stilbenes, and phenolics as determined by extensive spectroscopic methods, including 1D and 2D NMR. All the isolated compounds were evaluated for their Antiviral activity in HRV1B-, CVB3-, and EV71-infected cells. Among the tested compounds, three Flavonoids (4-6) and two Stilbenes (12 and 14) exhibited significant Antiviral activity. This is the first phytochemical investigation of C. latisiliqua twigs.

Keywords

Antiviral activity; Caesalpinia latisiliqua; Homoisoflavonoid; Leguminosae; Stilbenoid.

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