2. Academic Validation
  3. The Dual Roles of the Atypical Protein Kinase Cs in Cancer

The Dual Roles of the Atypical Protein Kinase Cs in Cancer

  • Cancer Cell. 2019 Sep 16;36(3):218-235. doi: 10.1016/j.ccell.2019.07.010.
Miguel Reina-Campos 1,  Maria T Diaz-Meco 1,  Jorge Moscat 2
Affiliations

Affiliations

  • 1 Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.
  • 2 Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: [email protected].
PMID: 31474570 DOI: 10.1016/j.ccell.2019.07.010
Abstract

Atypical protein kinase C (aPKC) isozymes, PKCλ/ι and PKCζ, are now considered fundamental regulators of tumorigenesis. However, the specific separation of functions that determine their different roles in Cancer is still being unraveled. Both aPKCs have pleiotropic context-dependent functions that can translate into tumor-promoter or -suppressive functions. Here, we review early and more recent literature to discuss how the different tumor types, and their microenvironments, might account for the selective signaling of each aPKC isotype. This is of clinical relevance because a better understanding of the roles of these kinases is essential for the design of new anti-cancer treatments.

Keywords

ECT2; Hedgehog; PD-L1; PHGDH; PKCζ; PKCλ/ι; SOX2; atypical PKCs; basal cell carcinoma; cancer; colorectal cancer; immunotherapy; kinase inhibitors; leukemia; lung cancer; metabolism; p62; polarity; prostate cancer; stroma; tumor promoter; tumor suppressor.

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