2. Academic Validation
  3. Four new flavonol glycosides from the leaves of Ginkgo biloba

Four new flavonol glycosides from the leaves of Ginkgo biloba

  • Nat Prod Res. 2021 Aug;35(15):2520-2525. doi: 10.1080/14786419.2019.1684282.
Yongxiang Wang 1 2 3,  Xue Xie 1 2 3,  Lina Liu 1 2 3,  Hongda Zhang 1 2 3,  Fuyong Ni 1 2 3,  Jianhui Wen 1 2 3,  Yun Wu 1 2 3,  Zhenzhong Wang 1 2 3,  Wei Xiao 1 2 3
Affiliations

Affiliations

  • 1 Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, People's Republic of China.
  • 2 State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People's Republic of China.
  • 3 Modern Chinese Medicine Innovation Cluster and Digital Pharmaceutical Technology Platform, Lianyungang, People's Republic of China.
PMID: 31680566 DOI: 10.1080/14786419.2019.1684282
Abstract

Four new flavonol glycosides, 5, 7, 5'-trihydroxy-3', 4'-dimethoxyflavonol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (1), quercetin 3-O-(6-trans-feruloyl)-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (2), kaempferol 3-O-(6-trans-caffeoyl)-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (3), myricetin 3-O-(6-trans-p-coumaroyl)-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (4), together with nine known Flavonoids and two known Lignans, were isolated from the leaves of Ginkgo biloba. Their structures were determined by extensive spectroscopic analyses. Their cardioprotective effects against H2O2-induced Apoptosis in H9c2 cells were also evaluated. The flavonol glycosides had stronger activity than the acylated flavonol glycosides at the concentration of 50 µM.

Keywords

Ginkgo biloba; acylated flavonol glycoside; cardioprotective activity.

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