2. Academic Validation
  3. Hexokinase II Inhibitory Effect of Secondary Metabolites Derived from a Streptomyces sp. Associated with Mud Dauber Wasp

Hexokinase II Inhibitory Effect of Secondary Metabolites Derived from a Streptomyces sp. Associated with Mud Dauber Wasp

  • Chem Biodivers. 2020 Jul;17(7):e2000140. doi: 10.1002/cbdv.202000140.
Xiu-Mei Zhang 1,  Ai-Hong Peng 2,  Wei-Dong Xie 2,  Mei Wang 1,  Dan Zheng 1,  Ming-Kuan Feng 1
Affiliations

Affiliations

  • 1 Department of Pharmacy, Shandong Drug and Food Vocational College, Weihai, 264210, P. R. China.
  • 2 Department of Pharmacy, College of Marine Science, Shandong University, Weihai, 264209, P. R. China.
PMID: 32515903 DOI: 10.1002/cbdv.202000140
Abstract

Insect-microbial symbioses have vast biochemical diversity, which is beneficial to produce bioactive secondary metabolites. In this study, chemical examination of a Streptomyces sp. associated with a mud dauber wasp led to the isolation of fourteen compounds. Their structures were determined by spectroscopic methods and comparison with literature data. Among the isolates, compounds 1,2,3-benzotriazin-4(1H)-one and 4-(2-aminoethyl)phenyl acetate were first reported from this species. Bioactivities of the isolated compounds were assayed for the first time against Hexokinase II. 4-(2-Aminoethyl)phenyl acetate, germicidin B, phenylacetic acid, isogermicidin A and germicidin C displayed significant inhibitory activity against Hexokinase II, with the IC50 values of 5.11, 7.11, 7.15, 8.45 and 8.78 μM, respectively.

Keywords

Streptomyces; hexokinase II inhibitory activity; mud dauber wasp; symbiose.

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