Germicidin B
Germicidin B is an antibiotic with bactericidal activity. Germicidin B inhibits hexokinase II with an IC50 of 25.16 μM. Germicidin B suppresses spore germination in Streptomyces. Germicidin B is applicable to studies on bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 150973-78-7
- Formula: C10H14O3
- Molecular Weight:182.22
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Antibiotic Isoforms
More
Biological Activity
|
hexokinase II 25.16 μM (IC50) |
Germicidin B (37 °C, 10 min) significantly inhibits the activity of purified hexokinase II, with an IC50 of 7.11 μM[1].
Germicidin B (0.01-1000 μg/mL) inhibits spore germination of Streptomyces [3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 150973-78-7
-
Molecular Weight 182.22
-
Formula C10H14O3
-
SMILES
O=C1OC(C(C)C)=CC(O)=C1CC
-
Structure Classification
-
Initial Source
Streptomyces Viridochromogenes
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Aoki Y, Matsumoto D, Kawaide H, Natsume M. Physiological role of germicidins in spore germination and hyphal elongation in Streptomyces coelicolor A3(2). J Antibiot (Tokyo). 2011 Sep;64(9):607-11. [Content Brief]
[2]. Zhang XM, et al. Hexokinase II Inhibitory Effect of Secondary Metabolites Derived from a Streptomyces sp. Associated with Mud Dauber Wasp. Chem Biodivers. 2020;17(7):e2000140. [Content Brief]
[3]. Song L, et al. Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. J Am Chem Soc. 2006;128(46):14754-14755. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz